Ozempic and its GLP-1 counterparts are no longer Hollywood’s best kept secret. What started as whispered speculation about sudden transformations on red carpets has turned into a growing chorus of celebrity voices speaking openly about weight loss medication. Their willingness to share is doing something quietly powerful and shifting the conversation from shame toward honesty.
Here are 15 well known figures who have spoken about their GLP-1 journeys, what worked, what did not, and what they want others to know.
Ozempic users who have spoken the loudest
Oprah Winfrey took her platform and turned it into a prime time moment, hosting a special on ABC dedicated entirely to the weight loss revolution sparked by GLP-1 drugs. She later revealed she had stopped taking the medication to prove she could maintain results on her own, gained back roughly 20 pounds over the following year, and returned to the drugs with a new perspective. She now views it as a lifelong commitment, much like blood pressure medication.
Serena Williams credited Zepbound with helping her lose 31 pounds after her second pregnancy, describing a feeling of being stuck despite intense training and clean eating. She has since become an ambassador for a telehealth provider and frames the medication as healthcare rather than a shortcut.
Rebel Wilson used Ozempic to help maintain the significant weight loss she achieved during what she called her year of health. She later stopped and described herself as content with where she landed, while being candid about having a complicated relationship with food.
Whoopi Goldberg shared on The View that Mounjaro played a role in her weight loss after she gained weight during steroid treatment while filming a major project. She used the moment to push back against the culture of judging people for how they look.
Charles Barkley lost around 60 pounds on Mounjaro alongside exercise and dietary changes, describing the experience as transformative and saying it made him feel human again. His stated motivation was longevity rather than appearance.
Kathy Bates lost 100 pounds over seven years, with the final 20 coming after she added Ozempic to her routine following a type 2 diabetes diagnosis. She paired the medication with walking and Pilates and described the overall journey as hard but worthwhile.
Meghan Trainor and her husband both used Mounjaro at the lowest dose alongside a dietitian, a trainer, and intentional lifestyle changes. She addressed public commentary about her appearance directly and described feeling strong and healthy rather than simply smaller.
Billie Jean King, now in her 80s, spoke openly about being a binge eater and said her doctor encouraged her to try a GLP-1 to help quiet the mental noise around food. She later confirmed she had begun the medication.
Jim Gaffigan lost 50 pounds on Mounjaro and expressed frustration at the stigma surrounding the drug, describing the result as a genuinely better quality of life.
Claudia Oshry took Ozempic until she and her husband decided to start a family, stopping the medication at that point. She was matter of fact about the decision from the beginning.
Elon Musk credited Wegovy alongside fasting for his physical transformation and has publicly advocated for making GLP-1 drugs more affordable and widely accessible.
Rosie O’Donnell began with Mounjaro at the lowest dose and has remained on it, pairing the medication with reduced sugar intake and more movement. She described still feeling surprised by her results years later.
Tracy Morgan has been among the most consistent public advocates for Ozempic, speaking about it on morning television and continuing to credit it with cutting his appetite significantly.
Chelsea Handler discovered she had been prescribed semaglutide without fully realizing it was Ozempic. After connecting the dots through a conversation with a friend, she eventually stopped taking the medication.
Amy Schumer had a difficult experience with Ozempic initially due to severe nausea and stopped. Years later she reported a much more positive experience with Mounjaro, combining it with hormone therapy during perimenopause.
What these stories actually tell us
Across all 15 accounts, a few things stand out. Results vary, side effects are real, and almost no one treats these medications as a permanent standalone solution. The celebrities who report the most satisfaction are those who paired the drugs with genuine lifestyle changes rather than relying on them exclusively. Their openness is not just celebrity oversharing. It is helping ordinary people feel less alone in a conversation that has long carried far too much stigma.
