Close this search box.

Rybelsus vs. Ozempic: Which is right for you?

woman with diabetes taking ozempic shot

Interest in glucagon-like peptide 1 agonists (GLP-1), a class of type 2 diabetes drugs that help manage blood sugar and may lead to weight loss, continues to grow. Two medications that often come up in this conversation are Rybelsus and Ozempic. Though both are manufactured by Novo Nordisk and contain semaglutide as the main active ingredient, one is an oral tablet, and the other is an injectable. Here, we break down their uses, dosages, ingredients, and more to help you decide which might be best for you.

Rybelsus vs. Ozempic uses

Both drugs help people with type 2 diabetes manage blood sugar and slow gastric emptying by mimicking the naturally occurring GLP-1 hormone in the body. They help decrease A1Cs, a blood test that indicates a three-month blood sugar average.

Rybelsus: Rybelsus is a prescription oral tablet that, when used alongside diet and exercise, improves blood sugar in adults with type 2 diabetes. It increases insulin released from the pancreas, decreases sugar released from the liver, and slows food leaving the stomach after eating. Though not intended for weight loss, it may help you lose weight.

Ozempic: Ozempic is a once-weekly injection used along with diet and exercise to improve blood sugar in adults with type 2 diabetes. It may help you lose weight and has shown heart-health benefits, gaining approval from the FDA to reduce the risk of heart attack, stroke, or death in adults with type 2 diabetes and known heart disease.


Rybelsus: Rybelsus comes in 3 mg, 7 mg, and 14 mg daily doses.

Ozempic: Ozempic is available in 0.25 mg, 0.5 mg, 1 mg, and 2 mg weekly doses.


Rybelsus: Rybelsus contains the active ingredient semaglutide and inactive ingredients, including magnesium stearate, microcrystalline cellulose, povidone, and salcaprozate sodium (SNAC).

Ozempic: Ozempic contains the active ingredient semaglutide and inactive ingredients, including disodium phosphate dihydrate, propylene glycol, phenol, and water for injection.

Which is more effective?

Ozempic is considered one of the strongest medications for diabetes and weight loss. Studies show that Ozempic users experience greater reductions in A1Cs and weight compared to Rybelsus users. However, the choice between the two depends on individual needs and preferences.


Rybelsus side effects: Common side effects include nausea, stomach pain, diarrhea, decreased appetite, vomiting, and constipation. More serious side effects may include thyroid tumors, pancreatitis, vision changes, low blood sugar, kidney problems, allergic reactions, and gallbladder issues.

Ozempic side effects: Common side effects include gastrointestinal upset, nausea, reflux, vomiting, diarrhea, constipation, and stomach pain. More serious side effects may include pancreatitis, appendicitis, thyroid cancer, decreased kidney function, allergic reactions, and angioedema.

Rybelsus vs. Ozempic: Which should I take?

Both medications are effective for managing type 2 diabetes. Ozempic may be stronger and offers FDA-approved heart health benefits, but it has more anecdotal side effects. Rybelsus may be preferred by those who find subcutaneous medications inconvenient or unsuitable.

Can someone switch between Rybelsus and Ozempic?

Yes, switching between the two is possible under the supervision of a health care provider. Patients taking Rybelsus 14 mg daily can transition to Ozempic 0.5 mg weekly and vice versa.

When to see a doctor

If you’re considering these medications or switching between them, consult a health care professional. Communicate your goals, whether they involve managing blood sugar levels, weight, heart health, or a combination of these objectives.